RECOTHROM Thrombin, topical (Recombinant) is the first thrombin approved by the US Food and Drug Administration that is produced via recombinant DNA technology. Recombinant proteins have opened up a new era of therapeutic care for a number of health conditions. Numerous recombinant proteins have been brought to market as alternatives to proteins derived from animal and human plasma: examples include human insulin and several human blood coagulation factors, among others. These proteins have been used safely and effectively for many different therapeutic indications. The availability of RECOTHROM offers a thrombin alternative that is plasma and bovine free.