12 CLINICAL PHARMACOLOGY

RECOTHROM Thrombin, topical (Recombinant), is a highly specific human serine protease that promotes hemostasis and acts locally when applied topically to a site of bleeding [see NONCLINICAL TOXICOLOGY (13.3)].  RECOTHROM activates platelets and catalyzes the conversion of fibrinogen to fibrin, which are steps that are essential for blood clot formation.